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BIOEN 215 Introduction to Bioengineering Problem Solving (3)
Introduces bioengineering through a problem solving approach. Topics include: creative problem solving techniques, self-directed inquiry, engineering ethics, social constraints, and engineering design process. Course overlaps with: TEE 225.

BIOEN 217 MATLAB Fundamentals for Bioengineers (1)
Introduction to scientific programming, using both standard programming methods and MATLAB-specific strategies. Intended as preparation for the Bioengineering core sequence. Applications include curve fitting, simulations, ODE solutions, and image processing fundamentals, executed as in-class tutorials and final project. Prerequisite: either CSE 121, CSE 122, CSE 123, CSE 142, CSE 160, or AMATH 301. Credit/no-credit only. Offered: AW.

BIOEN 290 Guided Independent Studies on Transformative Science (4) NSc
Intensive laboratory experience mixed with lectures, readings, and discussions aimed at achieving deep understanding of scientific approach, particularly the nature of paradigm shifts, role of governmental support and management of science, power of orthodoxy, role of challenger, and fate of unpopular scientific views. Offered: W.

BIOEN 299 Introduction to Bioengineering (1)
Lectures on the various aspects of bioengineering; orientation in bioengineering studies and practice. Credit/no-credit only. Offered: ASp.

BIOEN 315 Biochemical Molecular Engineering (3)
Introduces the requisite organic, physical, and biochemistry for incoming bioengineers to understand biological systems at the molecular level. Prerequisite: CHEM 223, CHEM 237 or CHEM 335; BIOL 200, which may be taken concurrently. Offered: Sp.

BIOEN 316 Biomedical Signals and Sensors (4)
Introduces the sources, detection, and processing of signals in medical instrumentation. Includes analog and digital signal processing in the time and frequency domains. Emphasizes component strengths and limitations, to develop systems that improve safety, accuracy, and reliability. Co-requisite: BIOEN 317 Prerequisite: either AMATH 301, both CSE 121 and BIOEN 217, both CSE 122 and BIOEN 217, both CSE 123 and BIOEN 217, both CSE 142 and BIOEN 217, or both CSE 160 and BIOEN 217; either PHYS 122 or PHYS 142; and either MATH 136, MATH 207, or AMATH 351, any of which may be taken concurrently. Offered: Sp.

BIOEN 317 Biomedical Signals and Sensors Laboratory (2)
Uses computational and experimental projects covering methods to acquire, process, and analyze signals from physiological and biochemical origins. Co-requisite: BIOEN 315 and BIOEN 316. Offered: Sp.

BIOEN 325 Biotransport I (4)
Introduces momentum and heat transport in medical and biological systems. Examines how differential and control-volume analyses produce ordinary and partial differential equations; develops analytical and computational solution methods. Prerequisite: either AMATH 301, both CSE 121 and BIOEN 217, both CSE 122 and BIOEN 217, both CSE 123 and BIOEN 217, both CSE 142 and BIOEN 217, or both CSE 160 and BIOEN 217; either MATH 136, MATH 207, or AMATH 351; and either PHYS 122 or PHYS 142. Offered: A.

BIOEN 326 Solid and Gel Mechanics (4)
Introduces solid mechanics and interactions of biological structures and medical materials. Emphasizes the relationships between composition, structure, properties, and performance of metals and ceramics, synthetic and natural macromolecules, cells, tissues, and self assembling systems. Prerequisite: either CHEM 162, CHEM 164, or CHEM 165; either PHYS 122 or PHYS 142; and a minimum grade of 2.0 in BIOEN 315. Offered: A.

BIOEN 327 Fluids and Materials Laboratory (2)
Practical exploration of the behavior of fluids and soft materials that occur in biological systems and biomedical devices; and the interaction between cells and their environment. Includes methods of measurement, analysis, and design. Co-requisite: BIOEN 325 and BIOEN 326. Offered: A.

BIOEN 335 Biotransport II (3)
Studies the principles of combined mass transport in homogeneous and heterogeneous reaction systems as applied to biological processes. Introduces chemical and biochemical reaction kinetics, methods of evaluating kinetic parameters for reaction rate data, and prediction of the performance of biological and biochemical processes. Prerequisite: minimum grade of 2.0 in BIOEN 325. Offered: W.

BIOEN 336 Bioengineering Systems and Control (3)
Reviews linear and nonlinear systems analysis and control system design and biological and medical applications. Prerequisite: a minimum grade of 2.0 in BIOEN 327; and either MATH 136, MATH 208, or AMATH 352. Offered: W.

BIOEN 337 Mass Transport and Systems Laboratory (2)
Uses computational and experimental laboratory exercises to demonstrate time- and space-dependent linear and nonlinear systems with specific emphasis on bioengineering application. Prerequisite: BIOEN 327; BIOEN 335 and BIOEN 336, which must be taken concurrently; and either STAT 311, STAT 390, Q SCI 381, or IND E 315, which may be taken concurrently. Offered: W.

BIOEN 345 Failure Analysis and Human Physiology (4)
Applies engineering analysis to understand human physiology of the engineering of solutions to medical and biological problems. Includes laboratory. Prerequisite: BIOL 220; a minimum grade of 2.0 in either of BIOEN 215 or ENGR 115; a minimum grade of 2.0 in BIOEN 335; a minimum grade of 2.0 in BIOEN 336; and a minimum grade of 2.0 in BIOEN 337. Offered: Sp.

BIOEN 400 Fundamentals of Bioengineering Design (3)
Preparatory project-based course that develops understanding of the engineering design process and incorporates modern tools and methodologies for developing innovative health technologies. Prerequisite: BIOEN 337; either STAT 311, STAT 390, Q SCI 381, or IND E 315; BIOL 220; and either PHYS 122 or PHYS 142. Offered: Sp.

BIOEN 401 Bioengineering Capstone Proposal (1)
Teaches proposal-writing principles and guides the development and planning of individually-based senior capstone projects. Co-requisite: BIOEN 400. Prerequisite: BIOEN 337. Offered: Sp.

BIOEN 402 Bioengineering Capstone Research and Design ([2-6]-, max. 10)
Independent senior design project. Prerequisite: BIOEN 401. Offered: AWSpS.

BIOEN 403 Bioengineering Capstone Research (2-, max. 4)
Independent senior research project. Prerequisite: BIOEN 401. Offered: AW.

BIOEN 404 Bioengineering Team Design I (3)
First course in team design project course sequence. Prerequisite: BIOEN 400. Offered: W.

BIOEN 405 Bioengineering Team Design II (4)
Second course in team design project course sequence. Prerequisite: BIOEN 404. Offered: Sp.

BIOEN 407 Bioengineering Nepal: Technology Assessment for Community and Global Health (5) NSc, DIV
Study abroad course that explores healthcare challenges faced globally in low-resource settings by studying clinical practice in Nepal. Students investigate healthcare delivery in a community hospital and a rural clinic, then evaluate clinical needs from holistic economic, social, and technological perspectives. Includes written analysis and public presentation of findings. Integrated with the Bioengineering Nepal Study Abroad program. Recommended: either G H 101/GEOG 180/JSIS B 180, G H 201, or BIOEN 215. Offered: jointly with G H 407; A.

BIOEN 410 Bioengineering Honors Seminar (1)
Service-learning for departmental honors students. Credit/no-credit only. Offered: A.

BIOEN 415 Bioconjugate Engineering (4)
Applies bioconjugate and molecular engineering methods for use in nanotechnology, drug delivery, biomaterials, diagnostics, medical devices, and biomedical research. Students learn how to engineer molecular and macromolecular systems using versatile bioconjugate techniques applicable to both industry and academia. Prerequisite: BIOEN 315, CHEM 221, CHEM 224, CHEM 239, or CHEM 337 Offered: A.

BIOEN 420 Medical Imaging (4)
Various medical imaging modalities (x-rays, CT, MRI, ultrasound, PET, SPECT optical imaging, etc.) and their applications in medicine and biology. Extends basic concepts of signal processing (BIOEN 303) to the two and three dimensions relevant to imaging physics, image reconstruction, image processing, and visualization. Prerequisite: either BIOEN 316 or E E 235; either MATH 136, MATH 208, or AMATH 352; and either CSE 142 or AMATH 301.

BIOEN 423 Introduction to Synthetic Biology (3)
Studies mathematical modeling of transcription, translation, regulation, and metabolism in cell; computer aided design methods for synthetic biology; implementation of information processing, Boolean logic and feedback control laws with genetic regulatory networks; modularity, impedance matching and isolation in biochemical circuits; and parameter estimation methods. Prerequisite: either MATH 136, MATH 207, MATH 307, AMATH 351, or CSE 311; and either MATH 208, MATH 308, or AMATH 352. Offered: jointly with CHEM E 476/CSE 486/E E 423.

BIOEN 424 Advanced Systems and Synthetic Biology (3)
Covers advanced concepts in system and synthetic biology. Includes kinetics, modeling, stoichiometry, control theory, metabolic systems, signaling, and motifs. All topics are set against problems in synthetic biology. Prerequisite: E E 423/BIOEN 423/CHEM E 476/CSE 486. Offered: jointly with CHEM E 477/CSE 487/E E 424.

BIOEN 425 Laboratory Methods in Synthetic Biology (4)
Designs and builds transgenic bacterial using promoters and genes taken from a variety of organisms. Uses construction techniques including recombination, gene synthesis, and gene extraction. Evaluates designs using sequencing, fluorescence assays, enzyme activity assays, and single cell studies using time-lapse microscopy. Prerequisite: E E 423/BIOEN 423/CHEM E 476/CSE 486; and either CHEM 142, CHEM 143, or CHEM 145. Offered: jointly with CHEM E 478/CSE 488/E E 425.

BIOEN 436 Quantitative Physiology (3)
Develops a foundation of human physiology by examining the homeostasis of vital parameters within the body, and the physiological properties of human cells, tissue, and organs. Recommended: MATH 207 or AMATH 351; courses in ordinary differential equations; probability theory; introductory programming; and introductory cell and molecular biology.

BIOEN 437 Computational Systems Biology (4)
Application of modeling in systems biology. Basic modeling techniques, standards and model repositories, model fitting, model selection and confidence estimates, uncertainty quantification, ensemble modeling and a term long modeling game. Prerequisite: either MATH 207 or AMATH 351; either MATH 208 or AMATH 352; and either CSE 121, CSE 122, CSE 123, CSE 142, CSE 160, or AMATH 301; recommended: BIOL 180 and BIOL 200.

BIOEN 440 Introduction to Biomechanics (4)
Presents the mechanical behavior of tissues in the body and the application to design of prostheses. Tissues studies include bone, skin, fascia, ligaments, tendons, heart valves, and blood vessels. Discussion of the structure of these tissues and their mechanical response to different loading configurations. An important part of the class is a final project. Offered: jointly with M E 445; Sp.

BIOEN 445 Contemporary Light Microscopy (3)
Introduction to the practical and theoretical foundations of light microscopy and advanced optical techniques used to study biological systems. Topics include the physics of light, physiology of the eye, photodetectors, bright field, dark field, and phase contrast microscopy; optical trapping; interference, polarization, and fluorescence; confocal and super-resolution microscopy; and image processing and machine learning strategies. Recommended: electromagnetism (PHYS 122 or equivalent); wave physics (PHYS 123 or equivalent); differential equations (either MATH 207, AMATH 351, or equivalent); and introductory biology (BIOL 200 or equivalent).

BIOEN 448 Bioacoustics and Therapeutic Ultrasound (4)
Principles of bioacoustics with applications to biomedical ultrasound, presented from an engineering viewpoint. Introduces principles of sound propagation, reflection, transmission, refraction, absorption, and bioeffects due to tissue interaction. Covers clinical applications, technology, and techniques and tools in modern therapeutic ultrasound procedures and devices. Discusses current challenges and opportunities in therapeutic ultrasound. Prerequisite: MATH 126 or MATH 136; PHYS 121 or PHYS 141; and PHYS 122 or PHYS 142. ; recommended: PHYS 123 or PHYS 143; experience with signal processing; linear systems; Fourier transforms; differential equations; linear algebra; and programming (MATLAB, Python, or similar).

BIOEN 449 Ultrasound Imaging (4)
Fundamentals of ultrasound leading to real-time ultrasound imaging. Introduces sound beams and signals; transducers, arrays and array beamforming; ultrasound interaction with tissue; diffraction integral and beamforming; B-mode, M-Mode, Doppler and Color-flow modes; nonlinear imaging and contrast agents; elastography, molecular imaging, and photoacoustic imaging. Prerequisite: either BIOEN 316 and BIOEN 317, E E 205 and E E 242, or E E 215 and E E 242. ; recommended: experience with differential equations; linear algebra; linear systems analysis; scientific programming; and introductory medical imaging.

BIOEN 450 Tissue Optics and Imaging (4)
Introduction to photobiology (interaction of light with biological matter), tissue optics, optical biosensors, and cellular and molecular imaging. Includes first-hand observation of optical imaging research in engineering and clinical labs, with case studies of optical biosensing and imaging in ophthalmological and dermatological applications. Prerequisite: either BIOEN 316, E E 242, PHYS 123, or PHYS 143; and either MATH 207, MATH 135, or AMATH 351; recommended: BIOEN 420; either MATH 208 or AMATH 352; and either PHYS 123 or PHYS 143.

BIOEN 451 Optical Coherence Tomography (4)
Describes the basic physics and engineering principles of optical coherence tomography, and rapid development of imaging applications in medicine and biology. Extends basic concepts of signal processing and instrumentation to imaging physics (optics), image reconstruction, image processing, and visualization. Prerequisite: either BIOEN 316 or E E 235; and either MATH 136, MATH 208, or AMATH 352; recommended: Contemporary Light Microscopy and Biophotonics Offered: A.

BIOEN 454 Bioengineering Solutions to Improve the Health of Families Worldwide (1) SSc, DIV
Seminar series that engages students in interdisciplinary discussions about global health. Explores how bioengineering approaches contribute to: (1) the study of problems of global health importance; (2) the development of diagnostics; and (3) the discovery of interventional strategies to improve human health. Emphasizes collaboration between students and researchers with backgrounds in infectious disease, basic science, and bioengineering. Credit/no-credit only. Offered: jointly with G H 454; A.

BIOEN 455 Biomicrofluidics (4)
Introduction to microfluidic technology and applications to biology and medicine. Topics include state-of-the-art techniques to fabricate microfluidic devices, such as micromachining, micromolding, and 3D printing, and to pattern cells and biomolecules. Covers biomedical challenges that can be addressed with microfluidic devices and associated engineering challenges. Through weekly labs, students design, fabricate, and test a microfluidic device. Prerequisite: BIOL 200; either PHYS 121 or PHYS 141; and either PHYS 122 or PHYS 142; recommended: experience or coursework in introductory circuits (either BIOEN 316, E E 215, or equivalent) and fluid mechanics (either BIOEN 325, M E 333, or equivalent).

BIOEN 457 Advanced Molecular Bioengineering (4)
Fundamentals of molecular recognition: thermodynamics, forces, kinetics. Manipulation of recognition processes for current molecular bioengineering research and development. Fundamental physical chemistry of molecular recognition in the context of biomedicine. Therapeutics based on cells. Prerequisite: either BIOEN 315 and BIOEN 335. Offered: A.

BIOEN 460 Neural Engineering (3)
Introduces the field of Neural Engineering: overview of neurobiology, recording and stimulating the nervous system, signal processing, machine learning, powering and communicating with neural devices, invasive and non-invasive brain-machine interfaces, spinal interfaces, smart prostheses, deep-brain stimulators, cochlear implants and neuroethics. Heavy emphasis on primary literature. Prerequisite: either BIOL 130, BIOL 162, or BIOL 220; and either MATH 208, AMATH 301, or AMATH 352. Offered: jointly with E E 460; A.

BIOEN 461 Neural Engineering Tech Studio (4)
Neural engineering design and translational engineering. Groups design, build and present a neural engineering prototype project to a panel of industry judges. Prerequisite: BIOEN 460/E E 460. Offered: jointly with E E 461.

BIOEN 463 Optogenetics (3)
Overview of optogenetics, which utilizes light-activated ion channels and fluorescent proteins to control and monitor neuronal activity through remote light stimulation in intact brain tissue. Includes (1) molecular basis, (2) tools and instrumentation, (3) experimental design, and (4) application range of optogenetic approaches. Builds a robust foundation for designing contemporary optogenetic experiments. Offered: W.

BIOEN 466 Neural Computation and Engineering Laboratory (4) NSc
Introduces neural recording and quantitative analysis techniques to students with a background in quantitative methods. Prerequisite: either BIOL 130, BIOL 162, BIOL 220, AMATH 342; and either MATH 208, AMATH 301, or AMATH 352. ; recommended: courses in scientific computing and matrix manipulations in Matlab; and courses in neural signal processing and data analysis. Offered: jointly with E E 466.

BIOEN 467 Biochemical Engineering (3)
Application of basic chemical engineering principles to biochemical and biological process industries such as fermentation, enzyme technology, and biological waste treatment. Rapid overview of relevant microbiology, biochemistry, and molecular genetics. Design and analysis of biological reactors and product recovery operations. Prerequisite: CHEM E 340; either CHEM 223, CHEM 237, or CHEM 335. Offered: jointly with CHEM E 467; W.

BIOEN 468 Real-Time Biosignal Processing (3)
Lab-based introduction to techniques for real-time signal acquisition, processing, and output, emphasizing software as an interface between user and electronic circuits. Students write programs for implementation both in graphical programming environments and in portable microprocessor platforms. In-depth discussion of hardware specifications and implications for circuit design. Prerequisite: Either BIOEN 316, or E E 215 and E E 235. Offered: W.

BIOEN 470 Systems Immunology and Immunoengineering (3)
Explores current progress towards a quantitative, systems-level understanding of immune system function. Topics include sensitivity and selectivity in immune receptor signaling, cell-cell coordination by cytokine communication, and cell engineering for immunotherapy. Prerequisite: MATH 207 or AMATH 351.

BIOEN 472 Biosensors for Cancer (4)
Introduces the broad field of biosensors for cancer diagnostics. Recommended: basic cancer biology, basic organic chemistry, basic materials science. Offered: A.

BIOEN 474 Immunoengineering (3)
Covers cell and tissues of immune system; lymphocyte activation and specificity; cell biology of antigen processing and preservation; and effector mechanisms. Includes discussion of concepts in theoretical immunology used to describe viral dynamics and the dynamics of immune responses. Students present case studies in the pathogenesis of immunologically mediated diseases. Offered: W.

BIOEN 475 Global Health Technology: Molecular Diagnostics (4)
Teaches engineering principles, tools, and technologies needed to practice or develop nucleic acid (DNA/RNA) diagnostics and their context in global health. Recommended: Advanced Engineering, Chemistry or math background. Offered: W.

BIOEN 481 Engineering Cell Biology (3)
Introduces engineering approaches for analysis and control of cell structure and function, and application of such technologies in cell biology studies. Covers the basics of cell biology, engineering cellular microenvironments, as well as effects of external engineering stimuli on cellular processes, which have significant implications in various diseases such as cancer, neuromuscular disease, and cardiovascular disease. Prerequisite: either CHEM 142, CHEM 143, or CHEM 145; and BIOL 200; recommended: Introductory Biology, General Chemistry

BIOEN 482 Cardiac Bioengineering (3)
Students discuss, present, and write literature reviews of scientific papers on the latest techniques, protocols and treatments being developed to treat heart failure and vascular diseases. Guest lecturers provide a clinical perspective, discuss clinical needs, and present their ongoing research and development projects. Prerequisite: BIOL 220; recommended: BIOEN 345.

BIOEN 483 Vascular Biology and Engineering (3)
Vascular Engineering has emerged to provide strategies for generating vascular grafts with long-term patency, and vascularized tissues for regenerative medicine and disease modeling. Focuses on understanding the structure and function of different vascular beds in vivo, and learning the cutting edge research and engineering principles in vascular biology and engineering. Recommended: Introductory Biology, General Mechanics, and Cell Biology Offered: W.

BIOEN 484 Computational Modeling and Simulation of Bioelectricity (3)
Explores multi-scale modeling of cardiac bioelectricity. Students learn biophysical theory in didactic lectures (e.g., ion channel kinetics, impulse propagation, arrhythmia) and conduct "virtual heart" experiments in hands-on sessions. Prerequisite: MATH 126 or MATH 136; PHYS 122 or PHYS 142; and either BIOEN 217, CSE 122 , CSE 160, or AMATH 301; recommended: introductory cardiovascular physiology (either BIOEN 345, P BIO 375, or equivalent).

BIOEN 485 Computational Bioengineering (4)
Introduction to computational and mathematical analysis of biological systems, including control, stochastic, and transport systems. Lectures and laboratory sessions emphasize biochemical systems, but also include electrical, mechanical, and fluidic systems. Prerequisite: BIOEN 335; and either AMATH 351 or MATH 207. Offered: Sp.

BIOEN 486 Tissue Engineering (3)
Tissue structure and function, scaffold design, applications to specialized tissues and organs. Prerequisite: BIOEN 315. Offered: W.

BIOEN 487 Bioengineering and Nanotechnology (3)
Explores basic concepts of nanoscience and the current literature, focusing on practical applications for nanotechnology in biology and medicine. Prerequisite: BIOL 180; either CHEM 142, CHEM 143, or CHEM 145; PHYS 121 or PHYS 141; and PHYS 122 or PHYS 142.

BIOEN 488 Computational Protein Design (4)
Explores methods in protein engineering, emphasizing biomedical and biotechnological applications. Includes molecular visualization, homology modeling, molecular dynamics, computational protein design, and evaluation of designs. Introduces current research in subject area. Students learn to use and apply computational tools to investigate design problems. Course overlaps with: B CHEM 310. Prerequisite: BIOEN 315. Offered: W.

BIOEN 489 Advanced Tissue Engineering (3)
Develops advanced knowledge in tissue engineering. Primarily through critical assessment of seminal publications in areas such as biomaterials, biofabrication, organ decellularization, cellular self-organization, organoids, and regenerative medicine. Students identify groundbreaking studies in tissue engineering and communicate the impact to other scientists and the public. Prerequisite: BIOEN 486.

BIOEN 490 Engineering Materials for Biomedical Applications (3)
Combined application of principles of physical chemistry and biochemistry, materials engineering, to biomedical problems and products. Applications include implants and medical devices, drug delivery systems, cell culture processes, diagnostics, and bioseparations. Offered: jointly with CHEM E 490; A.

BIOEN 491 Controlled-Release Systems (3)
Mechanisms for controlled release of active agents and the development of useful drug delivery systems for this purpose. Release mechanisms considered include diffusive, convective, and erosive driving forces. Delivery routes include topical, oral, and in vivo. Some special case studies covered in detail. Offered: jointly with CHEM E 491; W.

BIOEN 492 Surface Analysis (3)
Understanding of solid surfaces for research and development in microelectronics, catalysis, adhesion, biomaterials, science wear, and corrosion science. Newer methods available to study surfaces of materials. Electron emission spectroscopies (ESCA, Auger): ion scattering, ion spectroscopic, photon spectroscopic, and thermodynamic methods. Offered: jointly with CHEM E 458; Sp.

BIOEN 493 Advanced Surface Analysis (3)
Covers the latest advanced in surface analysis instrumentation and methodology, including advanced methods of biorecognition AFM, surface Plasmon resonance, x-ray photoelectron spectroscopy, sum frequency generation spectroscopy, time-of-flight secondary ion mass spectrometry, and multivariate analysis. Prerequisite: either CHEM E 458 or BIOEN 492. Offered: jointly with CHEM E 493; W.

BIOEN 494 Advanced Drug Delivery (3)
Provides students with an understanding of the current state of the art for advanced drug delivery. Covers the major families of biologic drugs, major challenges associated with their delivery and specific disease applications. Prerequisite: BIOEN 491. Offered: Sp.

BIOEN 497 Bioengineering Education Outreach (1-2, max. 6)
Work with K-12 schools or community organizations. Current science education research and instructional techniques. May involve presentations or instruction in hands-on activities. Credit/no-credit only.

BIOEN 498 Special Topics (1-6, max. 15)
Topics of current interest in the field, offered as lectures, conferences, or laboratory. Offered: AWSpS.

BIOEN 499 Special Projects (1-6, max. 24)
Individual undergraduate bioengineering projects (research or independent study) under the supervision of an instructor. Credit/no-credit only. Offered: AWSpS.

BIOEN 501 Molecular Bioengineering (4)
Examines advanced topics in molecular diffusion, reaction kinetics, and convective transport modeling as applied to biological systems. Includes mathematical analysis and numerical simulation techniques applied to: Non-Fickian diffusion, rotational versus translational diffusion, immobilized enzyme kinetics, drug release, and gene delivery.

BIOEN 502 Cellular Bioengineering (4)
Covers basic principles of cell biology (including cell structure, function, and signaling), recombinant RNA/DNA technology, and specific examples of cellular bioengineering applications including gene delivery, RNA silencing, and tissue engineering. Prerequisite: BIOEN 501.

BIOEN 503 Systems Bioengineering (4)
Explores whole-body or organ physiology topics from an engineering perspective. Uses various model systems to elucidate engineering principles such as feedback control and homeostatic regulation. Includes real-world examples, computer modeling, and research design approaches. Prerequisite: BIOEN 502.

BIOEN 504 Introduction to Technology Commercialization (4)
Explores essential business, legal, engineering, and other skills necessary to take new technology from research to market. Covers intellectual property, market analysis, licensing, funding mechanisms such as venture capital, and product marketing. Offered: A.

BIOEN 505 Biomedical Entrepreneurship (4)
Explores essential business, legal, engineering, and other skills necessary to take new technology from research to market. Covers intellectual property, market analysis, licensing, funding mechanisms such as venture capital, and product marketing; introduces strategic planning, management of commercialization effort. Offered: W.

BIOEN 506 Applying Technology Commercialization (1)
Focuses knowledge of entrepreneurship within the spaces of medical devices, hardware/software, and energy, into a practical description of a potential start-up company. Corequisite: ENTRE 540. Credit/no-credit only.

BIOEN 509 Bioengineering Departmental Seminar (1, max. 16)
Research review and discussions centered on demonstrating approaches and solving scientific problems. Seminar lectures led by faculty and visiting faculty in Bioengineering and related disciplines. Credit/no-credit only. Offered: WSp.

BIOEN 511 Biomaterials Seminar (1, max. 18)
Presentation of student research results. Prerequisite: permission of instructor. Credit/no-credit only. Offered: jointly with CHEM E 511.

BIOEN 513 Current Topics in Cardiac Physiology (1, max. 3)
Current research in cardiac physiology. Student presentation and discussions of current research methodologies. Credit/no-credit only.

BIOEN 515 Bioconjugate Engineering (4)
Applies bioconjugate and molecular engineering methods for use in nanotechnology, drug delivery, biomaterials, diagnostics, medical devices, and biomedical research. Students learn how to engineer molecular and macromolecular systems using versatile bioconjugate techniques applicable to both industry and academia. Recommended: Basic organic chemistry, biochemistry, molecular engineering Offered: A.

BIOEN 516 Medical Imaging Seminar (1)
Weekly seminars, presented by UW faculty members, researchers and graduate students from UW, other academic institutions, and industry, on image computing and medical imaging. Topics include digital video, image processing, computer graphics, video/image compression, image analysis, algorithms and systems, pattern recognition, multimedia computer architectures, and other applications. Credit/no-credit only.

BIOEN 518 Healthcare Transformation: Forces, Directions, Implications (2)
Introduces the history, current realities and forces driving change in healthcare and provides an opportunity to use this knowledge to evaluate contemporary attempts to innovate. Addresses implications for those involved in the science, technology, business and policy of medicine. Offered: W.

BIOEN 520 Musculoskeletal Biomechanics (4)
A broad introduction to musculoskeletal biomechanics, i.e., applying engineering mechanics to the human body. Examines: experimental techniques; anatomy; basic structure-function relationships; and implementation into research and commercial applications. Briefly covers scientific writing and presentations, literature reviews, and regulatory considerations. Offered: jointly with M E 527.

BIOEN 522 Biomechanics of Soft Tissue (3)
Applies soft tissue biomechanics to medical research. Develops specific biomechanical questions and experiments to address those aims or hypotheses.

BIOEN 523 Introduction to Synthetic Biology (3)
Studies mathematical modeling of transcription, translation, regulation, and metabolism in cell; computer aided design methods for synthetic biology; implementation of information processing, Boolean logic and feedback control laws with genetic regulatory networks; modularity, impedance matching and isolation in biochemical circuits; and parameter estimation methods. Prerequisite: either MATH 136, MATH 207, MATH 307, AMATH 351, or CSE 311; and either MATH 208, MATH 308, or AMATH 352. Offered: jointly with CHEM E 576/CSE 586/E E 523/MOLENG 525.

BIOEN 524 Advanced Systems and Synthetic Biology (3)
Covers advanced concepts in system and synthetic biology. Includes kinetics, modeling, stoichiometry, control theory, metabolic systems, signaling, and motifs. All topics are set against problems in synthetic biology. Prerequisite: E E 523/BIOEN 523/CHEM E 576/CSE 586/MOLENG 525. Offered: jointly with CHEM E 577/CSE 587/E E 524.

BIOEN 530 Bioengineering Professional Series I: Literature Analysis (2)
Skills in scientific literature analysis developed through topics in bioengineering. Credit/no-credit only. Offered: A.

BIOEN 531 Bioengineering Professional Series II: Proposal Writing (2)
Covers grant and fellowship proposal writing. Offered: W.

BIOEN 532 Bioengineering Professional Series III: Professional Skills Development (1)
Key areas of professional development related to the bioengineering field, including oral communication, management, networking, and interviewing. Credit/no-credit only. Offered: Sp.

BIOEN 536 Quantitative Physiology (3)
Develops a foundation of human physiology by examining the homeostasis of vital parameters within the body, and the physiological properties of human cells, tissue, and organs. Recommended: MATH 107, AMATH 351, or equivalent; courses in ordinary differential equations; probability theory; introductory programming; and introductory cell and molecular biology.

BIOEN 537 Computational Systems Biology (4)
Application of modeling in systems biology. Basic modeling techniques, standards and model repositories, model fitting, model selection and confidence estimates, uncertainty quantification, ensemble modeling and a term long modeling game. Recommended: coursework in differential equations; linear algebra; and introductory biology; and either coursework or experience coding in Python (preferred), MATLAB or equivalent.

BIOEN 540 Bioengineering Clinical Practicum (2)
Clinical needs identification for the Master of Applied Bioengineering. Students observe diagnosis and treatment in a clinical setting to learn current practice, drivers, and constraints. Students learn to identify and communicate clinical needs not met by current technology, but with potential bioengineering design solutions. Addresses ethics, patient privacy, and medical/academic communication. Credit/no-credit only. Offered: A.

BIOEN 541 Design Skills I: Clinical Needs Evaluation (4)
First quarter of Design Skills sequence in Master of Applied Bioengineering. Student teams initiate design process through needs evaluation, market analysis, prior art research, identification of design specifications, and brainstorming of design concepts. Offered: A.

BIOEN 542 Design Skills II: Clinical Needs Evaluation (4)
Second quarter of Design Skills sequence. Students conceive, evaluate, and present design options to potential clinical users, utilize feedback to revise design concepts, and prepare a formal design proposal. Prerequisite: BIOEN 541 Offered: W.

BIOEN 543 Design Skills III: Project Implementation (4)
Culmination of the three-quarter Design Skills sequence in the Master of Applied Bioengineering. Students create and test a proof-of-principle deliverables for the device or system proposed in the previous quarter, and prepare a formal business plan. Prerequisite: BIOEN 542. Offered: Sp.

BIOEN 544 Advanced Clinical Design Project (1-10)
Summer-long culminating design experience in which student teams generate and test a solution to meet desired clinical needs. Prerequisite: BIOEN 543 Offered: S.

BIOEN 545 Contemporary Light Microscopy (3)
Introduction to the practical and theoretical foundations of light microscopy and advanced optical techniques used to study biological systems. Topics include the physics of light, physiology of the eye, photodetectors, bright field, dark field, and phase contrast microscopy; optical trapping; interference, polarization, and fluorescence; confocal and super-resolution microscopy; and image processing and machine learning strategies. Recommended: electromagnetism (PHYS 122 or equivalent); wave physics (PHYS 123 or equivalent); differential equations (either MATH 207, AMATH 351, or equivalent); and introductory biology (BIOL 200 or equivalent).

BIOEN 546 Fundamentals of Biomedical Imaging: X-ray and Nuclear (4)
Explores core principles of biomedical imaging with a focus on x-ray and nuclear imaging. Fundamental concepts common to all modalities are reviewed: Multi-dimensional Fourier transforms, the imaging equation, the inverse problem, image SNR, and contrast agents. Lectures will emphasize a systems approach that is reinforced though computational mini projects using Matlab. Recommended: Signal and systems (linear systems), Fourier transforms and advanced linear algebra, scientific programming (e.g. Matlab or other languages). Offered: A.

BIOEN 548 Bioacoustics and Therapeutic Ultrasound (4)
Principles of bioacoustics with applications to biomedical ultrasound, presented from an engineering viewpoint. Introduces principles of sound propagation, reflection, transmission, refraction, absorption, and bioeffects due to tissue interaction. Covers clinical applications, technology, and techniques and tools in modern therapeutic ultrasound procedures and devices. Discusses current challenges and opportunities in therapeutic ultrasound. Prerequisite: differential, integral, and introductory multivariable calculus (MATH 126 or equivalent); mechanics (PHYS 121 or equivalent); and introductory electromagnetism (PHYS 122 or equivalent); recommended: experience or coursework in wave mechanics (PHYS 123 or equivalent); experience with signal processing; linear systems; Fourier transforms; differential equations; linear algebra; and programming (MATLAB, Python, or similar).

BIOEN 549 Ultrasound Imaging (4)
Fundamentals of ultrasound leading to real-time ultrasound imaging. Introduces sound beams and signals; transducers, arrays and array beamforming; ultrasound interaction with tissue; diffraction integral and beamforming; B-mode, M-Mode, Doppler and Color-flow modes; nonlinear imaging and contrast agents; elastography, molecular imaging, and photoacoustic imaging. Prerequisite: introductory electrical circuits, Fourier analysis, frequency filtering, and digital signal processing, with lab experience (either BIOEN 316 and BIOEN 317, or E E 215 and E E 242, or equivalent); recommended: experience with differential equations; linear algebra; linear systems analysis; scientific programming (e.g. MATLAB); and introductory medical imaging.

BIOEN 550 Tissue Optics and Imaging (4)
Introduction to photobiology (interaction of light with biological matter), tissue optics, optical biosensors, and cellular and molecular imaging. Includes first-hand observation of optical imaging research in engineering and clinical labs, with case studies of optical biosensing and imaging in ophthalmological and dermatological applications. Recommended: differential equations; linear algebra; introductory electromagnetics; waves and light; signal processing, including Fourier analysis and linear systems.

BIOEN 551 Optical Coherence Tomography (4)
Describes the basic physics and engineering principles of optical coherence tomography, and rapid development of imaging applications in medicine and biology. Extends basic concepts of signal processing and instrumentation to imaging physics (optics), image reconstruction, image processing, and visualization. Recommended: Signal processing and linear systems (at a level of BIOEN 316) Mathematical skills (at a level of AMATH352) Physics level at PHYS 122 BIOEN 498/599: Contemporary Light Microscopy and Biophotonics Offered: A.

BIOEN 552 Microfabrication and Microfluidics (3)
Studies the use of 2- and 3-dimensional structures in research and biomaterials, cells, and complex liquids. Focuses on micropatterning of surfaces and microfluidic chemical analytical systems. Co-requisite: BIOEN 553.

BIOEN 553 Microfabrication and Microfluidics Laboratory (2)
Studies the creation of 2- and 3-dimensional structures for use in research with biomaterials, cells, and complex liquids. Each student will fabricate at least one PDMS device and demonstrate its function. Co-requisite: BIOEN 552. Credit/no-credit only.

BIOEN 554 Bioengineering Solutions to Improve the Health of Families Worldwide (1/2)
Seminar series that engages students in interdisciplinary discussions about global health. Explores how bioengineering approaches contribute to (1) the study of problems of global health importance, (2) the development of diagnostics, and (3) the discovery of interventional strategies to improve human health. Emphasizes collaboration between students and researchers with backgrounds in infectious disease, basic science, and bioengineering. Credit/no-credit only. Offered: jointly with G H 554; A.

BIOEN 555 Water, Nature, and Biological Function (3)
Explores emerging concepts of water at interfaces as a new and simpler way to understand many features of chemistry, physics, and biology. Considers new understanding in cell function, energy transduction, solar energy, flow, transport, weather, green science, and other basics of nature and engineering.

BIOEN 557 Advanced Molecular Bioengineering (4)
Covers fundamentals of molecular recognition and design: thermodynamics, dynamics, and kinetics. Includes molecular design of macromolecules, recognition processes for current molecular engineering applications in biomedicine, and therapeutics based on cells. Offered: jointly with MOLENG 515; A.

BIOEN 560 Neural Engineering (3)
Introduces the field of Neural Engineering: overview of neurobiology, recording and stimulating the nervous system, signal processing, machine learning, powering and communicating with neural devices, invasive and non-invasive brain-machine interfaces, spinal interfaces, smart prostheses, deep-brain stimulators, cochlear implants and neuroethics. Heavy emphasis on primary literature. Offered: jointly with E E 560; A.

BIOEN 561 Neural Engineering Tech Studio (4)
Neural engineering design and translational engineering. Groups design, build and present a neural engineering prototype project to a panel of industry judges. Prerequisite: BIOEN 560 Offered: jointly with E E 561; W.

BIOEN 563 Optogenetics (3)
Overview of optogenetics, which utilizes light-activated ion channels and fluorescent proteins to control and monitor neuronal activity through remote light stimulation in intact brain tissue. Includes (1) molecular basis, (2) tools and instrumentation, (3) experimental design, and (4) application range of optogenetic approaches. Builds a robust foundation for designing contemporary optogenetic experiments. Offered: W.

BIOEN 566 Neural Computation and Engineering Laboratory (4)
Introduces neural recording and quantitative analysis techniques to students with a background in quantitative methods. Offered: jointly with E E 564.

BIOEN 568 Real-Time Biosignal Processing (3)
Lab-based introduction to techniques for real-time signal acquisition, processing, and output, emphasizing software as an interface between user and electronic circuits. Students write programs for implementation both in graphical programming environments and in portable microprocessor platforms. In-depth discussion of hardware specifications and implications for circuit design. Recommended: Basic Electrical Engineering Offered: W.

BIOEN 570 Systems Immunology and Immunoengineering (3)
Explores current progress towards a quantitative, systems-level understanding of immune system function. Topics include sensitivity and selectivity in immune receptor signaling, cell-cell coordination by cytokine communication, and cell engineering for immunotherapy.

BIOEN 572 Biosensors for Cancer (4)
Introduces the broad field of biosensors for cancer diagnostics. Offered: A.

BIOEN 573 Biosensors and Biomedical Sensing (3)
In-depth introduction to the principal types of biosensors. Topics include comparison of sensor types, fabrication techniques, sensor operation, use of biological molecules in sensing, and applicability of particular sensor types to biomedical sensing applications. Recommended: experience or introductory coursework in general chemistry (CHEM 152 or equivalent); organic chemistry; biology (BIOL 200 or equivalent); mechanics; electromagnetism; biochemistry; wave mechanics; fluid mechanics; and human pathology.

BIOEN 574 Immunoengineering (3)
Covers cell and tissues of immune system; lymphocyte activation and specificity; cell biology of antigen processing and preservation; and effector mechanisms. Includes discussion of concepts in theoretical immunology used to describe viral dynamics and the dynamics of immune responses. Students present case studies in the pathogenesis of immunologically mediated diseases. Offered: W.

BIOEN 575 Global Health Technology: Molecular Diagnostics (4)
Teachers engineering principles, tools, and technologies needed to practice or develop nucleic acid (DNA/RNA) diagnostics and their context in global health. Recommended: Advanced Engineering, Chemistry or math background. Offered: W.

BIOEN 576 Laboratory Techniques in Protein Engineering (4)
Practical introduction to fundamentals of recombinant DNA technology and protein engineering. Gene design, bacterial molecular biology, genetic engineering strategy. Laboratory project focused on making site-directed protein mutations. Techniques include the Polymerase Chain Reaction, DNA sequencing, DNA cutting/splicing, protein expression. Prerequisite: background in biochemistry or molecular biology or permission of instructor.

BIOEN 577 Cell and Protein Reaction with Foreign Materials (3)
Study of ways in which cell and protein interactions with foreign materials affect the biocompatibility of biomaterials. Description of phenomenology and mechanisms of protein adsorption, mammalian cell adhesion, and cell receptor biology and of methods used to study these phenomena. Surface properties of materials discussed in context of the course. Prerequisite: permission of instructor.

BIOEN 578 Biomembranes (3)
Develops an understanding of the molecular principles that underlie the self-assembly of surfactants into natural and model membranes; in particular, on the relationship between the chemical structure of lipid molecules and the three-dimensional aggregates that they form in water.

BIOEN 579 Host Response to Biomaterials (3)
Basic cell and molecular biology of the pathologies associated with biomaterial implantation that limit bioprosthetic use, including hemostasis, infection, acute and chronic inflammation, wound healing and fibrosis, and structural alterations. Major methods for histological analysis of retrieved implants. Prerequisite: general biology, BIOEN 490 (may be taken concurrently), or permission of instructor.

BIOEN 581 Engineering Cell Biology (3)
Introduces engineering approaches for analysis and control of cell structure and function, and application of such technologies in cell biology studies. Covers the basics of cell biology, engineering cellular microenvironments, as well as effects of external engineering stimuli on cellular processes, which have significant implications in various diseases such as cancer, neuromuscular disease, and cardiovascular disease. Recommended: Introductory Biology, General Chemistry Offered: A.

BIOEN 582 Cardiac Bioengineering (3)
Students discuss, present, and write literature reviews of scientific papers on the latest techniques, protocols and treatments being developed to treat heart failure and vascular diseases. Guest lecturers provide a clinical perspective, discuss clinical needs, and present their ongoing research and development projects.

BIOEN 583 Vascular Biology and Engineering (3)
Vascular Engineering has emerged to provide strategies for generating vascular grafts with long-term patency, and vascularized tissues for regenerative medicine and disease modeling. This course focuses on understanding the structure and function of different vascular beds in vivo, and learning the cutting edge research and engineering principles in vascular biology and engineering. Recommended: Introductory Biology, General Mechanics, and Cell Biology Offered: W.

BIOEN 584 Computational Modeling and Simulation of Bioelectricity (3)
Explores multi-scale modeling of cardiac bioelectricity. Students learn biophysical theory in didactic lectures (e.g., ion channel kinetics, impulse propagation, arrhythmia) and conduct "virtual heart" experiments in hands-on sessions. Recommended: multivariable calculus (MATH 126); introductory electromagnetism (PHYS 122); computer programming (either BIOEN 217, CSE 122 , CSE 160, AMATH 301, or equivalent); and basic cardiovascular physiology (either BIOEN 345, P BIO 375, or equivalent).

BIOEN 585 Computational Bioengineering (4)
Introduction to computational and mathematical analysis of biological systems, including control, stochastic, and transport systems. Lectures and laboratory sessions emphasize biochemical systems, but also include electrical, mechanical, and fluidic systems.

BIOEN 586 Tissue Engineering (3)
Tissue structure and function, scaffold design, applications to specialized tissues and organs. Offered: W.

BIOEN 587 Bioengineering and Nanotechnology (3)
Explores basic concepts of nanoscience and the current literature, focusing on practical applications for nanotechnology in biology and medicine.

BIOEN 588 Computational Protein Design (4)
Explores methods in protein engineering, emphasizing biomedical and biotechnological applications. Includes molecular visualization, homology modeling, molecular dynamics, computational protein design, and evaluation of designs. Introduces current research in subject area. Students learn to use and apply computational tools to investigate design problems.

BIOEN 589 Advanced Tissue Engineering (3)
Develops advanced knowledge in tissue engineering. Primarily through critical assessment of seminal publications in areas such as biomaterials, biofabrication, organ decellularization, cellular self-organization, organoids, and regenerative medicine. Students identify groundbreaking studies in tissue engineering and communicate the impact to other scientists and the public. Recommended: BIOEN 586.

BIOEN 590 Advanced Topics in Biomaterials (3)
Major, controversial issues in application of synthetic materials to medical problems. Blood compatibility, bioadhesion, intraocular lenses, contact lenses, polyurethanes, biodegradation, protein adsorption, corrosion, bone fixation, new materials, artificial heart, medical device regulation. Prerequisite: BIOEN 490 or CHEM E 490. Offered: jointly with CHEM E 590.

BIOEN 591 Controlled Release Systems (3)
Provides students with an understanding of the current state of the art for advanced drug delivery. Covers the major families of biologic drugs, major challenges associated with their delivery and specific disease applications. Offered: W.

BIOEN 592 Surface Analysis (3)
Understanding of solid surfaces for research and development in microelectronics, catalysis, adhesion, biomaterials science, wear and corrosion science. Newer methods available to study surfaces of materials. Electron emission spectroscopies (ESCA, Auger); ion scattering, ion spectroscopic, photon spectroscopic, and thermodynamic methods. Offered: jointly with CHEM E 558.

BIOEN 593 Advanced Surface Analysis (3)
Covers the latest advanced in surface analysis instrumentation and methodology, including advanced methods of biorecognition AFM, surface Plasmon resonance, x-ray photoelectron spectroscopy, sum frequency generation spectroscopy, time-of-flight secondary ion mass spectrometry, and multivariate analysis. Prerequisite: either CHEM E 558 or BIOEN 592. Offered: jointly with CHEM E 593; W.

BIOEN 594 Advanced Drug Delivery (3)
Provides students with an understanding of the current state of the art for advanced drug delivery. Covers the major families of biologic drugs, major challenges associated with their delivery and specific disease applications. Offered: Sp.

BIOEN 598 Research Rotation (1-10, max. 30)
Research rotation in the laboratories of core or adjunct faculty in the Department of Bioengineering. Credit/no-credit only. Offered: AWSpS.

BIOEN 599 Special Topics in Bioengineering (1-6, max. 30)
Offered at a graduate level periodically by faculty members within the Department of Bioengineering; concerns areas of research activities with current and topical interest to bioengineers. Prerequisite: undergraduate or graduate courses (or equivalent) determined individually for each special topic.

BIOEN 600 Independent Study or Research (*-)
Offered: AWSpS.

BIOEN 601 Internship (1-10, max. 10)
Bioengineering graduate internship program. Requires written report. Prerequisite: permission of supervisory committee chair. Offered: AWSpS.

BIOEN 700 Master's Thesis (*-)
Offered: AWSpS.

BIOEN 800 Doctoral Dissertation (*-)
Offered: AWSpS.